|
KMID : 0043320080310111489
|
|
Archives of Pharmacal Research
2008 Volume.31 No. 11 p.1489 ~ p.1496
|
|
|
Antidiabetic Activity of Angelan Isolated from Angelica gigas Nakai
|
|
Han Sang-Bae
Kim Young-Soo
Hong Jin-Tae
Kang Jong-Soon
Kim Hwan-Mook
Kim Yeon-Jin
Kim Ji-Yoon
Lee Ki-Ho
Park Song-Kyu
|
|
|
Abstract
|
|
|
|
Angelan isolated from Angelica gigas Nakai inhibits tumor growth and metastasis by enhancing immune functions of macrophages, dendritic cells, and B cells. Here, we report that angelan can inhibit autoimmunity in non-obese diabetic (NOD) mice. Although 80% of the NOD mice had developed diabetes by 24 weeks of age, none of the angelan-treated NOD mice developed diabetes. The mean glucose levels were 118 mg/dl in angelan-treated mice and 506 mg/dl in control NOD mice. Histological examination of the pancreatic islets revealed that most of the islets isolated from angelan-treated mice were less infiltrated with lymphocytes compared with those of control mice. Spleen cells from diabetic NOD mice could adaptively transfer diabetes into NOD.scid mice, but those from angelan-treated NOD mice did not, suggesting that angelan caused the spleen cells to lose the ability to destroy β cells. However, angelan did not affect cytokine production of spleen cells. These results suggest that angelan has dual immunomodulatory functions, i.e., immunostimulation in tumor-bearing mice and immunosuppression in autoimmune diabetic mice.
|
|
|
KEYWORD
|
|
|
Angelan, Angelica gigas Nakai, Autoimmune diabetes, Non-obese diabetic mice, Immunomodulation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|